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Major Bioactive Components in MIP Colostrum

The most important components of colostrum can be broken down into three major categories: Immune System Factors, Insulin-like Growth Factors and Nutritional Components.

Immune System Factors

Proline-Rich Polypeptides (PRPs): Proline-rich polypeptides (PRPs) act systemically, modulating the complex immune system and are therefore the most important ingredient in colostrum. They help regulate the thymus gland (bodies central command for the immune system), stimulating an underactive immune system or down-regulating an overactive immune system.

Immunoglobulins (IgG, IgA, IgE, IgM, IgD): The average IgG amount in MIP Colostrum powder is around 20-25%. Immunoglobulins are also known as antibodies. These small proteins are used by the immune system to seek out and destroy foreign antigen invaders. Laboratory analyses of both immune and growth factors from bovine colostrum indicate that they are identical to those found in human colostrum. Except for the fact that the levels of these factors are significantly higher in the bovine version.

Bovine colostrum is 40 times richer in immune factors than human colostrum.

For example, human colostrum contains 2% of IgG (immunoglobulin G). Cow colostrum contains 86% of IgG, the most important of the immunoglobulins found in the body.

Lactoferrin: Lactoferrin is an iron-binding protein that helps deprive bacteria of the iron they require to reproduce and releases iron into the red blood cells enhancing oxygenation of tissues. Lactoferrin modulates cytokine release and its receptors have been found on most immune cells including lymphocytes, monocytes, macrophages and platelets.

α – Lactalbumin and β – Lactoglobulin: These are the major nutritional whey proteins in milk and colostrum.

Cytokines: Cytokines are small proteins that are secreted by specific cells of the immune system. They are proteins, peptides or glycoproteins and are a category of signalling molecules that are used extensively in cellular communication.  They help to boost T-cell activity, and help to regulate the bodies response to exercise and other stimuli.

Lysozymes: Lysozymes help support the immune system.

Enzymes: Lactoperidase-thiocyanate, peroxidase, and xanthine oxidase oxidize bacteria through their ability to release hydrogen peroxide.

Glycoproteins: Glycoproteins are a digestive factor that has been shown to help immune and growth factors survive the passage through the highly acidic digestive system.

Insulin-like Growth Factors (IGFs)

IGFs are very small bio-active molecules which promote growth and maturation of various cell types and tissues. They are found in very high concentrations in MIP Colostrum. IGFs not only stimulate normal growth and development but also help regenerate and accelerate the repair of aged or injured muscle, skin, bone, cartilage and nerve tissues. IGFs also help build lean muscle and have been shown to have a positive effect on athletic performance, therefore, MIP Colostrum is increasingly being used in bodybuilding regimes.

Nutritional Components

Vitamins, Minerals, Amino Acids, and Essential Oils: Colostrum is a combination of vitamins, minerals, and amino acids that are naturally occurring in a perfect combination. Vitamins A, B1, B2, B6, B12, and E are found in small amounts while traces of all other vitamins, as well as minerals such as calcium, sodium, magnesium and zinc are also present in colostrum. Colostrum is a rich source of both essential and non-essential amino acids as well as essential fats including phospholipids which enable colostral protein protection and easy absorption in the gut by forming liposomes around them.

MIP Colostrum is the ultimate in preserving all the natural transfer factors, increasing and enhancing the bioavailability of the growth and immune factors to us.

Supporting Products

References

McGrath BA, Fox PF, McSweeney PLH, Kelly AL. Composition and properties of bovine colostrum: a review. Dairy Science & Technology, 2016 Mar; 96(2):133-158. Doi: 10.1007/s13594-015-0258-x. Retrieved from: https://link.springer.com/article/10.1007/s13594-015-0258-x

Yamauchi K, Wakabayashi H, Hashimoto S, et al. Effects of orally administered bovine lactoferrin on the immune system of healthy volunteers. Adv Exp Med Biol .1998; 443:261-5.

Di Mario F, Aragona G, Dal Bó N, et al. Use of bovine lactoferrin for Helicobacter pylori eradicationDig Liver Dis 2003; 35: 706 – 10.

Journal of Applied Physiology IGF-I, IgA, and IgG responses to bovine colostrum supplementation during training