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Green Lipped Mussel and Inflammation

Green lipped mussel is a type of shellfish endemic to New Zealand. This particular shellfish is well-known for its therapeutic uses. For many years, green lipped mussel has been used as an additional tool to manage a number of health conditions and support overall health. How does green lipped mussel work? The driving force behind the efficacy of this shellfish is its potent anti-inflammatory effect. Here, we discuss how green lipped mussel helps reduce inflammation.

What is Inflammation?

At the very beginning, it is important to define inflammation due to many misconceptions about it. Essentially, inflammation is the body’s effort to protect itself from invaders, pathogens, viruses, and other harmful bodies and substances. It is the inflammation that helps the body heal and protect you from a number of health conditions. That being said, chronic and excessive inflammation is bad news and poses as an underlying cause for autoimmune diseases, health conditions, and cancer.

Green Lipped Mussel and Inflammation

Anti-inflammatory benefits of green lipped mussel aren’t a marketing trick used to make you want to purchase the product; they are scientifically-proven facts. For example, a study from the Inflammo Pharmacology showed that the ingredient inhibits biosynthesis of leukotriene-B4 (leukotriene involved in inflammation) by stimulated human polymorphonuclear leukocytes (types of white blood cells) and prostaglandin-E2 (a principal mediator of inflammation) production by activated human macrophages (immune system cells)[1].

In addition, the Journal of the International Society of Sports Nutrition published a study which found that supplementation with green lipped mussel can also attenuate inflammation after exercise. Scientists discovered that intake of the supplement significantly attenuated muscle damage and inflammation and it was also associated with less strength loss than placebo[2].

As seen above, green lipped mussel has the amazing potential to block inflammatory processes that occur due to exercise and diseases; thus confirming that intake of the supplement is beneficial for disease management and overall health support.

Omega-3 fatty acids

Green lipped mussel is high in Omega-3 fatty acids which are essential for overall health and wellbeing. These fatty acids are well-known for their ability to reduce inflammation. A growing body of evidence confirms that Omega-3s exhibit anti-inflammatory effects through multiple mechanisms including acting through cell surface and intracellular receptors that control inflammatory cell signalling and gene expression patterns[3]. This could also explain why Omega-3 fatty acids play a major role in treatment and management of numerous inflammatory diseases including rheumatoid arthritis.

Vitamin C

The shellfish is a great source of vitamin C and although we don’t usually consider it as an anti-inflammatory agent, it could play a role in relieving inflammation. How? Studies show that oxidative stress and inflammation are closely related and tightly linked processes. Even though one may appear after the other, when one of them appears in the body the chances are high the other factor will form as well[4]. Now it is a good time to mention that vitamin C functions as an antioxidant and has the potential to prevent or reduce oxidative damage. Plus, one study showed that vitamin C has potential effects in alleviating inflammatory status in hypertensive, diabetic, and obese individuals[5].


Glutamine is one of 20 naturally-occurring amino acids, but it is also found in green lipped mussel. Evidence shows that glutamine has anti-inflammatory and a moderate analgesic (pain-relieving) activity[6] too.

Green Lipped Mussel from NutriNZ

Green Lipped Mussel from NutriNZ is an all-natural dietary supplement that enriches the body with highly-quality extract of the shellfish sourced from reputable marine farms. The shellfish is accompanied with rosemary oil with powerful antioxidant properties. The regular intake of the supplement relieves inflammation and helps improve quality of life in an entirely natural and safe manner.

Supporting Products


[1] Whitehouse MW, Macrides TA, Kalafatis N, et al. Anti-inflammatory activity of a lipid fraction (lyprinol) from the NZ green-lipped mussel. InflammoPharmacology 1997 Sep, vol. 5 no. 3, 237-246 https://link.springer.com/article/10.1007/s10787-997-0002-0

[2] Mickleborough TD, Sinex JA, Platt D, et al. The effects PCSO-524, a patented marine oil lipid and Omega-3 PUFA blend derived from the New Zealand green lipped mussel (Perna canaliculus), on indirect markers of muscle damage and inflammation after muscle damaging exercise in untrained men: a randomized, placebo controlled trial. Journal of the International Society of Sports Nutrition 2015 Feb, 12:10. Doi: 10.1186/s12970-015-0073-z https://jissn.biomedcentral.com/articles/10.1186/s12970-015-0073-z

[3] Calder PC. Omega‐3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology? British Journal of Clinical Pharmacology. 2013;75(3):645-662. doi:10.1111/j.1365-2125.2012.04374.x. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575932/

[4] Subrata Kumar Biswas. Does the interdependence between oxidative stress and inflammation explain the antioxidant paradox? Oxidative Medicine and Cellular Longevity 2016. Doi: 10.1155/2016/5698931 https://www.hindawi.com/journals/omcl/2016/5698931/

[5] Ellulu MS, Rahmat A, Patimah I, Khaza’ai H, Abed Y. Effect of vitamin C on inflammation and metabolic markers in hypertensive and/or diabetic obese adults: a randomized controlled trial. Drug Design, Development and Therapy. 2015;9:3405-3412. doi:10.2147/DDDT.S83144. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492638/

[6] Jain P, Khanna NK. Evolution of anti-inflammatory and analgesic properties of L-glutamine. Agents and Actions 1981 May;11(3):243-9 https://www.ncbi.nlm.nih.gov/pubmed/7257951